Author/Authors :
0، 0 0 نويسنده 1Department of Medical Laboratory Sciences, School Igaro, Osaretin God Igaro , 0، 0 0 نويسنده Department of Chemical Pathology, Toxicology and M I. Anetor, John , 0، 0 0 نويسنده Basel Convention Coordinating Centre for Training Osibanjo, Oladele O. Osibanjo , 0، 0 0 نويسنده Department of Medical Laboratory Sciences, School Benedo Osadolor, Humphrey , 0، 0 0 نويسنده Chemical Pathology Laboratory, Faith MediPlex Hosp Idomeh, Festus A. , 0، 0 0 نويسنده Department of Medical Laboratory Sciences, School Osazee Igiewe, Wiliams , 0، 0 0 نويسنده Department of Medical Laboratory Sciences, School Uzoma Kalikwu, Ogochukwu
Abstract :
< div id="__if72ru4sdfsdfrkjahiuyi_once" style="display: none;" > < /div > < div id="__if72ru4sdfsdfruh7fewui_once" style="display: none;" > < /div > < div id="__zsc_once" > Large volumes of mostly irreparable electronic waste (e-waste) are shipped to Africa on a monthly basis, of which Nigeria receives the largest share. E-waste management practices in Nigeria have remained completely primitive until date; and e-waste workers have little or no occupational safety knowledge and devices. The thousands of chemicals in e-waste have been reported to be toxic to human health in any degree of exposure. The present study has assessed the risk of liver damage in workers occupationally exposed to e-waste in Benin City, South-south Nigeria in 2014. Serum activities of liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) and alkaline phosphatase (ALP)]; and levels albumin (ALB), total bilirubin (T/Bil) and conjugated bilirubin (C/Bil) were determined using standard colorimetric methods. Serum Alpha fetoprotein (AFP) was determined using ELISA in Nigerian e-waste workers (n=63) and in age-matched unexposed participants (n=41) in Benin City. The results showed significantly raised activities of enzymatic biomarkers of liver damage (ALT, AST, ALP and GGT) in the e-waste group compared with the unexposed participants. There was no significant difference in the levels of ALB, T/Bil and C/Bil between exposed and unexposed participants. AFP levels in e-waste workers (3.56 ± 0.34 ng/mL) were significantly different compared with the unexposed group (2.14 ± 0.80 ng/mL) ( < em > P < /em > < 0.045). The significantly elevated cancer risk biomarker (AFP) and the enzymatic biomarkers of liver damage observed in the Nigerian e-waste workers studied may be associated with occupational exposure to known carcinogens and hepatotoxic metals in e-waste. < /div > < div id="__hggasdgjhsagd_once" style="display: none;" > < /div >
