Author/Authors :
Golfakhrabadi، Fereshteh نويسنده Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Golfakhrabadi, Fereshteh , Khanavi، Mahnaz نويسنده , , Ostad، SeyedNasser نويسنده Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences
Research Center, Tehran University of Medical Sciences, Tehran, Iran. Ostad, SeyedNasser , SAEIDNIA، SOODABEH نويسنده , , Vatandoost، Hassan نويسنده , , Abai، MohammadReza نويسنده Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Abai, MohammadReza , Hafizi، Mitra نويسنده Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Hafizi, Mitra , Yousefbeyk، Fatemeh نويسنده Department of Pharmacognosy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran. Yousefbeyk, Fatemeh , RazzaghiRad، Yaghoob نويسنده Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. RazzaghiRad, Yaghoob , Baghenegadian، Ameneh نويسنده Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Baghenegadian, Ameneh , Shams-Ardekani، Mohammadreza نويسنده Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran Shams-Ardekani, Mohammadreza
Abstract :
Background: Ferulago carduchorum Boiss and Hausskn belongs to the Apiaceae family. This plant grows in west part of Iran that local people added it to dairy and oil ghee to delay expiration date and give them a pleasant taste. The aim of this study was to investigate the antioxidant, antimicrobial, acetyl cholinesterase inhibition, cytotoxic, larvicidal activities and composition of essential oil of F. carduchorum.
Methods: Acetyl cholinesterase (AChE) inhibitory, larvicidal activities and chemical composition of essential oil of F. carduchorum were investigated. Besides, antioxidant, antimicrobial and cytotoxic activities of essential oil were tested using DPPH, microdilution method and MTT assay, respectively.
Results: The major components of essential oil were (z)-β-ocimene (43.3%), α-pinene (18.23%) and bornyl acetate (3.98%). Among 43 identified components, monoterpenes were the most compounds (84.63%). The essential oil had noticeable efficiency against Candida albicans (MIC= 2340 μg ml-1) and it was effective against Anopheles
stephensi with LC50 and LC90 values of 12.78 and 47.43 ppm, respectively. The essential oil could inhibit AChE (IC50= 23.6 μl ml-1). The essential oil showed high cytotoxicity on T47D, HEP-G2 and HT-29 cell lines (IC50< 2 μg ml-1).
Conclusion: The essential oil of F. carduchorum collected from west of Iran had anti-Candida, larvicidal and cytotoxicity effects and should be further investigated in others in vitro and in vivo experimental models.
