Author/Authors :
Rafinejad، A. نويسنده 1 Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran , , Fallah Tafti، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical sciences, Tehran, I.R.Iran. , , Tiwari، R. نويسنده 2 Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA , , Foroumadi، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. , , Akbarzadeh، T. نويسنده ,
Abstract :
In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.
