Author/Authors :
Bagheri، Babak نويسنده Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran Bagheri, Babak , Shokrzadeh، Mohammad نويسنده Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IR Iran , , Mokhberi، Vahid نويسنده , , Azizi Boroujerdi، Soheil نويسنده Department of Management, Allame Tabatabaei University, Tehran, Iran , , Khalilian، Alireza نويسنده , , Akbari، Negin نويسنده Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran Akbari, Negin , Habibi ، Valiallah نويسنده Student Research Committee, Mazandaran University of Medical Sciences, Sari, IR Iran , , Yousefnejad، Keyvan نويسنده Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran , , Tabiban، Sasan نويسنده Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran , , Nabati، Maryam Nabati نويسنده Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran ,
Abstract :
Background: Coronary Artery Disease (CAD) is the most important cause of mortality in the world. About half of cardiovascular risk factors have not been completely understood. Oxidation of LDL by oxidants such as iron plays a central role in atherogenesis. As a result, evaluation of the iron stores is important in the risk evaluation of the atherosclerotic disease.
Materials and Methods: This cross sectional study was performed on 337 patients with chronic stable angina hospitalized in Sari heart center, Mazandaran University of Medical Sciences from February 2010 to July 2012. Coronary angiography was performed and the angiograms were evaluated by two cardiologists. Moreover, blood samples were collected after a 14-hour fast immediately before the coronary angiography in order to measure the total cholesterol, HDL- cholesterol, and glucose. The patients were divided into four groups to evaluate the severity of Coronary Artery Disease (CAD) according to Syntax scoring system.
Results: The study results revealed a significant difference among the four study groups regarding the iron serum level. It was significantly higher in the sever atherosclerosis group compared to the normal (P=0.0122), mild (P=0.023), and moderate CAD groups (P < 0.001).
Conclusions: The findings indicated that the serum level of iron was higher in the atherosclerotic patients and increased with the severity of CAD. Therefore, a basic relationship probably exists between the serum iron level and CAD. Further prospective and experimental studies are needed to confirm the association between the iron status and atherosclerosis.
