Author/Authors :
Abbaspour، Mohammadreza نويسنده Nanotechnology Research Center and School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran Abbaspour, Mohammadreza , Sharif Makhmalzadeh، Behzad نويسنده Nanotechnology Research Center and School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , , Rezaee، Behjat نويسنده Nanotechnology Research Center, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , , Shoja، Saeed نويسنده Department of Microbiology, Infectious and Tropical Diseases Research Center, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran , , Ahangari، Zohreh نويسنده Department of Endodontic, Dental Research Center of Shahid Beheshti University of Medical Science, Tehran, Iran ,
Abstract :
Background: Chitosan, an important biodegradable and biocompatible polymer, has demonstrated wound-healing and antimicrobial properties.
Objectives: This study aimed to evaluate the antimicrobial properties of mafenide acetate-loaded nanofibrous films, prepared by the electrospinning technique, using chitosan and polyvinyl alcohol (PVA).
Materials and Methods: A 32 full factorial design was used for formulating electrospinning solutions. The chitosan percentage in chitosan/PVA solutions (0%, 10%, and 30%) and the drug content (0%, 20%, and 40%) were chosen as independent variables. The release rate of mafenide acetate from nanofibrous films and their microbial penetration were evaluated. The antimicrobial activity of different nanofibrous film formulations against Staphylococcus aureus and Pseudomonas aeruginosa was studied.
Results: The results indicated that all nanofibrous films, with and without drug, can prevent bacterial penetration. Incorporation of mafenide acetate into chitosan/PVA nanofibers enhanced their antimicrobial activity against P. aeruginosa and S. aureus.
Conclusions: Overall, the results showed that chitosan/polyvinyl alcohol (PVA) nanofibrous films are applicable for use as a wound dressing with protective, healing, and antimicrobial effects.
