Author/Authors :
Hosseinpanah، Farhad نويسنده Research Center of Obesity, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Daneshpour، Maryam Sadat نويسنده Cellular and Molecular Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Ahmadi، Nazanin نويسنده Research Center of Obesity, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Behnami، Sara P. نويسنده Research Center of Obesity, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Azizi، Fereidoin نويسنده Research Center of Endocrine, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran ,
Abstract :
Osteoporosis is a systemic disease with a strong genetic component. Vitamin D receptor (VDR) gene is associated with inter-individual variance in bone mineral density (BMD). The aim of this study was to assess the association between BMD and the VDR gene polymorphisms. A total of 233 women including 124 premenopausal and 109 postmenopausal women, who were older than 40 years old, were randomly selected from the participants of Tehran Lipid and Glucose Study (TLGS). Serum 25 (OH) vitamin D, calcium, and phosphorus levels were measured and body mass index (BMI), BMD of femoral neck, total femoral, trochanteric, and lumbar spine bones were calculated. The polymerase chain reaction (PCR) was used to determine the Bsm1 and Tru91 polymorphisms of VDR gene. According to PCR results, Bb genotype frequencies in premenopausal and postmenopausal woman were 39.5% and 31.2%, respectively, and Tt genotype frequencies were 41.9% and 33%, respectively. Moreover, b and T alleles were more frequent in these women, with a frequency of 0.57% and 0.18%, respectively. In premenopausal subjects, the mean BMD at all sites were higher in bb group than in the BB group (P < 0.05). After adjustment for age, BMI, and serum 25 (OH) D, the bb group had lower BMD at all these sites in postmenopausal women; however, the difference was insignificant. There was no association between Tru91 polymorphism and BMD in premenopausal and postmenopausal women. It seems that there is a possible interaction between premenopausal status and the Bsm1 polymorphism of VDR gene polymorphism and the BMD levels in these regions.
