Author/Authors :
Zucchini، Cinzia نويسنده Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy , , Sanctis، Paola De نويسنده Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy , , Facchini، Chiara نويسنده The Minimally Invasive Gynecological Surgery Unit, Department of Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy , , Donato، Nadine Di نويسنده Pelvic Endoscopy and Minimally Invasive Gynaecologic Surgery, St. Orsola Malpighi University Hospital, Bologna, Italy , , Montanari، Giulia نويسنده The Minimally Invasive Gynecological Surgery Unit, Department of Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy , , Bertoldo، Valentina نويسنده Pelvic Endoscopy and Minimally Invasive Gynaecologic Surgery, St. Orsola Malpighi University Hospital, Bologna, Italy , , Farina، Antonio نويسنده Department of Medicine and Surgery DIMEC, Division of Prenatal Medicine, St. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy , , Seracchioli، Renato نويسنده The Minimally Invasive Gynecological Surgery Unit, Department of Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy ,
Abstract :
Background: The aim of this study is to compare the circulating placental growth
factor (PlGF) concentration in women with and without endometrioma to verify the
performance of this marker to diagnose the disease.
Materials and Methods: In this case-control study, thirteen women with histological diagnosis
of ovarian endometriosis were compared with women without endometriosis disease.
PlGF plasma levels of endometriotic patients and controls were investigated using a fluorescence
immunoassay technique.
Results: PlGF showed a direct correlation with body mass index (BMI) only in the
control group (P=0.013). After adjustment for BMI values, PlGF median value in
endometriosis group (14.7 pg/mL) resulted higher than in control group (13.8 pg/
mL, P=0.004).
Conclusion: PlGF is a promising peripheral blood marker that can discriminate between
patients with and without ovarian endometriosis.
