Author/Authors :
Zahiri، Ziba نويسنده Reproductive Health Research Center, Obstetrics and Gynecology Department, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran , , SHARAMI، SEYEDEH HAJAR نويسنده , , Milani، Forozan نويسنده Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran. Milani, Forozan , Mohammadi، Fereshteh نويسنده , , Kazemnejad، Ehsan نويسنده Department of Community Medicine, Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran Kazemnejad, Ehsan , Ebrahimi، Hannan نويسنده Student of Medicine ,Guilan University of Medical Sciences, Guilan, Iran. , , Dalil Heirati، Seyedeh Fatemeh نويسنده Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract :
Background: The prevalence of metabolic syndrome (MetS) in polycystic ovary syndrome
(PCOS) has been studied in different populations, but their results were so controversial
regarding Iranian women. These controversial data indicated the need for more
investigation of MetS characteristics in PCOS patients in our population. So this study
aimed to evaluate the clinical and laboratory characteristics and metabolic features of
patients with PCOS in Rasht.
Materials and Methods: This prospective cross sectional study was conducted on
215 PCOS women who lived in Rasht, north of Iran, from March 2010 to July 2012.
The participants were then divided into two groups of women with MetS (n=62)
and women without MetS (n=153). The diagnosis of PCOS and MetS were based
on the Rotterdam 2003 criteria and the Adult Treatment Panel III (ATP III) criteria,
respectively. Demographic characteristics, fertility characteristics, family history
and laboratory findings were assessed.
Results: The prevalence of MetS in women with PCOS was 28.8%. In PCOS women
of both groups, the waist circumference (WC) exceeded 88cm in 72.6%, hypertension
[systolic blood pressure (SBP) and/or diastolic blood pressure (DBP)
?130/85mm Hg] was prevalent in 9.3%, fasting blood sugar (FBS) level was ?110
mg/dl in 6%, triglycerides (Tg) level were ?150 mg/dl in 47%, and high-density
lipoprotein (HDL) level was < 50 mg/dl in 86%. The values of WC, SBP, DBP, body
mass index (BMI), ovarian size, Tg, cholesterol, FBS, 2-hour blood sugar, aspartate
aminotransferase (AST), and alanine aminotransferase (ALT) were significantly
greater in PCOS women with MetS than women without MetS. Also HDL and luteinizing
hormone (LH) levels in women with MetS were significantly lower than
women without MetS.
Conclusion: Prevalence of MetS in PCOS women was 28.8%, indicating that this value is
higher than other studies conducted on PCOS women in Iran and other studies conducted
on general population in Iran. PCOS women are considered as a high-risk population for
MetS. The special strategies are required to prevent MetS and its associated complications
in PCOS women.
