Author/Authors :
Ahmadi Jebelli، Mohammad نويسنده Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, IR Iran , , Kalantar ، Enayatollah نويسنده Envirronmental Health Resaerch Center,KurdistanniversityofMedical Sciences, Sanandaj, Iran Kalantar , Enayatollah , Maleki، Afshin نويسنده Kurdistan Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran , , Izanloo، Hassan نويسنده Department of Environmental Health Engineering, Research Center for Environment Pollutants, Qom University of Medical Sciences, Qom, Iran , , Gharibi، Fardin نويسنده Vice Chancellor of Research, Kurdistan University of Medical Sciences, Sanandaj, Iran , , Daraei، Hiua نويسنده Kurdistan Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran , , Hayati، Bagher نويسنده Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, IR Iran , , Ghasemi، Ehsan نويسنده , , Azari، Ali نويسنده Cardiovascular Research Center, Ghaem Hospital AND Atherosclerosis Prevention Research Center, Imam Reza Hospital, AND Department of Cardiac Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract :
Dendrimers are a new class of polymeric materials with the well-defined structure, composition and architecture. Owing to antibacterial properties of dendrimers, they can be used as alternative water and wastewater disinfection with the minimum adverse side effects. The aim of the present study was to evaluate the antibacterial activity of second generation poly propylene imine (PPI- G2) dendrimer on predominant bacteria in drinking water resources. In this qualitative and interventional study, a total of 764 water samples were collected from rural areas in Qom Province, Iran, and bacteria were isolated and identified using standard procedures. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against gram-positive and gram-negative bacteria were determined according to clinical and laboratory standards institute (CLSI) guideline. Standard discs were prepared using different concentrations of dendrimer on Mueller-Hinton agar plates. The most important isolated bacteria were Escherichia coli 37 (48.7%), Klebsiella oxytoca 12 (15.8%), Proteus mirabilis 3 (4%), Entrobacter aerogenes 8 (10.5%), Citrobacter freundii 4 (5.2%), Pseudomonas aeruginosa 5 (6.6%), Staphylococcus aureus 2 (2.6%), and Bacillus subtilis 5 (6.6%). Moreover, it was found that PPI-G2 showed more potent activity towards the gram-positive bacteria than the gram-negative ones. The PPI-G2 dendrimer with end amine groups exhibited a positive impact on the removal of dominant bacterial isolated strains. Therefore, it is possible to use these nanodendrimers as a safe and effective material for water disinfection in the future
