Material hazards are the most important risk in scientific laboratories. In risk assessment processing, the potential impact of assessor personal judgment is the most important issue. This study tried to develop a risk assessment pattern based on Failure Mode and Effect Analysis (FMEA) and Analytical Hierarchy Process (AHP) logics and empirical data in scientific laboratories. The most important issues were high pressure reservoirs and hardware failure fuel.The other type of data about building plan, evacuation procedure and ability of hazard detection were also collected. Both groups of data were used as input to construct the model. Information integration plays a key role in the performance of fire and spillage risk assessment. For this purpose, a method based on analytical hierarchy process theories was applied to investigate the multi-hierarchy and multi-factor assessment problems. Testing the conceptual model for material risk assessment was performed in the proposed site. The results showed that the Laboratories of Sciences and Research Campus of Azad University were not suitably safe according to the fire and spillage risk assessment model. To reduce the risk probability, all of occupants in the buildings were required to be trained and automatic fire fighting and spillage detection system and adjustable fire exit and emergency stairs should be installed.