Association between Angiotensinogen M235T Polymorphism and Preeclampsia in Iranian Pregnant Women.
Afshariani، Raha نويسنده Public Health Department, Faculty of School of Health, Shiraz University of Medical Sciences, Shiraz, IR Iran Afshariani, Raha , Roozbeh، Jamshid نويسنده , , Sharifian، Maryam نويسنده Department of Fishery, Faculty of Fisheries and Environment, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran , , Ghaedi، Mahbobeh نويسنده Urology Nephrology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Ghaedi, Mahbobeh , Samsami Dehaghani، Alamtaj نويسنده Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran , , Ghaderi، Abbas نويسنده ,
Objective:To determine the possible association between the M235T variant of angiotensinogen gene and preeclampsia in Iranian preeclamtic women with hypertension during pregnancy. Mand methods:During a case control study, we used polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis to investigate the association between M235T polymorphism in preeclamtic women compared to normotensive controls.
Results:The M235T polymorphism was significantly associated with increased preeclampsia risk in the studied population as supported by a p value of 0.017 and chi-square value of 8.12. The frequency of mutated allele and genotype distribution showed a significant difference between preeclamtic women and control groups.
Conclusion:The result indicates that the AGT M235T polymorphism plays a significant role in preeclampsia observed in selected Iranian preeclamtic women, and it can be considered as a major risk factor for preeclampsia.