Title of article :
Association Between Toxin-Antitoxin Systems and Biofilm Formation
Author/Authors :
Karimi، Sajedeh نويسنده Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, IR Iran , , Ghafourian، Sobhan نويسنده Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, IR Iran , , Taheri-Kalani، Morovat نويسنده Faculty of Medicine , , Azizi Jalilian، Farid نويسنده Dept. of Medical Microbiology, Ilam University of Medical Sciences, Ilam, Iran , , Hemati، Saeed نويسنده Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, IR Iran , , Sadeghifard، Nourkhoda نويسنده Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Sadeghifard, Nourkhoda
Issue Information :
فصلنامه با شماره پیاپی 41 سال 2015
Pages :
6
From page :
1
To page :
6
Abstract :
Background: Toxin-antitoxin (TA) systems are found on the chromosomes and plasmids of many Bacteria such as Escherichia coli. The roles of TA systems in bacteria are enigmatic. Multiple biological functions of TA systems are proposed including growth modulation, persistence, and biofilm formation. Biofilms of E. coli are cause of urinary tract infections, as well as bacteraemia. Objectives: The current study aimed to find the association between biofilm formation and toxin-antitoxin systems in clinical isolates of E. coli. Materials and Methods: A total of 150 E. coli isolates were evaluated for biofilm formation by Congo red agar medium (CRA) and microtiter plate assay and the presence of different TA systems including MazEF, RelBE, hipBA, ccdAB and MqsRA. Results: The results of the analysis revealed that 107 E. coli isolates were potent for biofilm formation by CRA. The findings by microtiter plates showed that 102 E. coli isolates were biofilm producers. The results indicated that 80%, 85%, 70%, 91% and 82% of the isolates possessed MazEF, RelBE, hipBA, ccdAB and MqsRA TA loci, respectively. Conclusions: The analysis recommended that TA genes are prevalent in clinical isolates of E. coli strains. The analysis revealed that hipBA TA system is associated with biofilm formation.
Journal title :
Jundishapur Journal of Microbiology (JJM)
Serial Year :
2015
Journal title :
Jundishapur Journal of Microbiology (JJM)
Record number :
2384310
Link To Document :
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