The comparability of Second dose Thiopental with Lidocaine in The attenuation of Cardiovascular response to Endotracheal intubation

Background: This study was carried out to appraise the usefulness of second dose thiopental for hemodynamic response to laryngoscopy and intubation. Patients and Methods: The present study comprised 120 patients aged 15 to 65 years who were divided into four groups each of 30 patients. Patients in each group were given 2 µg/kg fentanyl iv, 4 mg/kg thiopental for induction of anesthesia, followed by 0.5 mg/kg atracurium for muscle relaxation and a second dose of thiopental (1mg/kg in group I, 2mg/kg in group II) immediately prior to laryngoscopy and intubation, lidocaine 1.5 mg/kg (group III) or normal saline 5 ml (group IV) 2 minutes prior to larygoscopy and intubation. The heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), and rate pressure product (RPP) were determined before induction of anaesthesia and laryngoscopy (baseline) , and at 1min (T1), 3min(T3), 5min(T5), and 10min (T10) after laryngoscopy and intubation. Results: Our findings demonstrated similar effects of lidocaine and second dose thiopental 2mg/kg on attenuation of DAP, MAP, RPP, and HR changes at 1, 3, and 5 min after endotracheal intubation (EI). Conclusion: Second dose thiopental can be employed as a substitute for lidocaine in attenuation of cardiovascular response to intubation in patients devoid of ischemic heart disease.