Author/Authors :
Jabari، Maryam نويسنده Department of Phamacagnozi , , Asghari، Gholamreza نويسنده , , Ghanadian، Mostafa نويسنده Department of Phamacagnozi , , Jafari، Azizullah نويسنده Department of Phamacagnozi , , Yousefi، Hosseiail نويسنده Department of Parasitology , , Jafari ، Rasool نويسنده Department of Parasitology and Mycology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , , Sharafi، Seyedeh Marayam نويسنده Infectious Diseases and Tropical Medicine Research Center , , Yousofi Darani، Hossein نويسنده Parasitologist, Professor, Dept of Parasitology, Shahrekord University of Medical Sciences, Shahrekord ,
Abstract :
Introduction: Trichomonas vaginalis (T. vaginalis) is a protozoan parasite causing trichomoniasis or trichomonal vaginitis. The infection is considered as non-viral sexually transmitted disease (STD). Metronidazole and Tinidazole are now the drugs of choice for the treatment of this infection. However, resistant to these drugs has also been reported. So it is necessary to search for effective alternative drugs with fewer side effects. Chaerophyllum macropodum (C. macropodum) plant have been used against some parasites. Therefore, in this study the effects of different extracts of this plant on T. vaginalis in culture media have been investigated.
Methods: In this experimental study hydro-ethanol extracts of C. macropodum leaves were prepared. Anti-T. vaginalis activities of the extracts were tested in concentrations of 2, 4, 8, 16, 32, 40, 50, 60, 80, 100 and 150 mg/ml following 24, 48 and 72 hours of incubation of cultured media.
Results: All extract concentrations showed some degrees of growth inhibition activity on T. vaginalis. However crude extract was more efficient.
Conclusion: C. macropodum showed an anti-T. vaginalis activity. More investigations are recommended to use this plant as an antiparasitic drug.
