Author/Authors :
Ali، Nesma A نويسنده Department of Chemical Laboratories, Forensic Medicine Authority, Justice Ministry,114 Bairam El Tounsy St., El SayedaZeinab, Cairo, Egypt Ali, Nesma A , Abdelrahman، Maha M نويسنده Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., 62514, Beni-Suef, Egypt Abdelrahman, Maha M , Naguib، Ibrahim A نويسنده Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Alshaheed Shehata Ahmad Hegazy St., 62514, Beni-Suef, Egypt Naguib, Ibrahim A , El Ghobashy، Mohamed R نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., 11562, Cairo, Egypt El Ghobashy, Mohamed R
Abstract :
Polyvinyl chloride (PVC) membrane sensor is described and characterized for the determination of a Benzodiazepine drug; bromazepam (BMZ). The sensor based on the use of the ion association complex of BMZ cation with tetraphenyl borate (BMZ-TPB) counter anion as ion exchange sites in the PVC matrix plasticized with dibutylsebathete (DBS) as a solvent mediator. The performance characteristics of thissensor were evaluated according to IUPAC recommendations; achieve a fast, stable and linear response for BMZ over the concentration range 10–6 to 10–2 M with slope of 44.13 mV per concentration decade. The direct potentiometric determination of BMZ using the proposed sensor gave average recovery of 100.05±0.66. The sensor is used for determination of BMZ in pharmaceutical formulations and in plasma. Validation of the method shows suitability of the proposed sensor for use in the quality control assessment of BMZ. The developed method was proved to be simple, accurate and precise when statistically compared with a reference HPLC method
