Author/Authors :
Rafiei Tabatabaei، Sedigheh نويسنده Pediatric Infections Research Center, Department of Pediatric Infectious Diseases, Shahid Beheshti University of Medical Sciences , , Amanati، Ali نويسنده Hamadan University of Medical sciences, Hamadan, Iran , , Karimi، Abdollah نويسنده , , Goudarzipour، Kourosh نويسنده Pediatric Congenital Hemathologic Disorders Research
Center, Shahid Beheshti University of Medical Sciences, Tehran, IR
Iran , , Chavoshzadeh، Zahra نويسنده , , Kazemi Aghdam، Maryam نويسنده Pediatric Pathology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , , Haghighi، Mohammad Bagher نويسنده Mofid Children’s Hospital, Shahid Beheshti University of
Medical Sciences, Tehran, IR Iran ,
Abstract :
There are increasing reports of serious adverse events of bacillus Calmette-Guerin (BCG) vaccination in infants with unrecognized primary immunodeficiency disorders (PIDs) in our country. Among these adverse events skin manifestations occur less frequently and are less noticed. We report on an 11-months-old boy with prolonged fever and diffuse hyperpigmented subcutaneous nodules. Due to lymphopenia, oral thrush and severe adverse reaction to BCG vaccination, the possibility of primary immunodeficiency was considered for him and immunological investigations were done. Subcutaneous nodules in the absence of a local reaction at the site of BCG vaccination may be the sole manifestation of disseminated BCG disease
