Title of article
The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats
Author/Authors
-، - نويسنده Department of Physiology, School of Medicine, Jiroft university of medical Sciences, Jiroft, Iran Anaeigoudari, Akbar , -، - نويسنده Neurogenic Inflammation Research Center & Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hosseini, Mahmoud , -، - نويسنده Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Karami, Reza , -، - نويسنده Neurogenic Inflammation Research Center & Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Vafaee, Farzaneh , -، - نويسنده Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammadpour, Toktam , -، - نويسنده Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Ghorbani, Ahmad , -، - نويسنده Neurocognitive Research Center & Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sadeghnia, Hamid Reza
Issue Information
دوماهنامه با شماره پیاپی 0 سال 2016
Pages
13
From page
223
To page
235
Abstract
-
Abstract
Objective: In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. Materials and Methods: The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (NBF) of C. sativum (25 and 100 mg/kg), and (5) ethyl acetate fraction (EAF) of C. sativum (25 and 100 mg/kg). Results: The first generalized tonic-clonic seizures (GTCS) latency in groups treated with 100 mg /kg of WF or EAF was significantly higher than that of PTZ group (p< 0.01). In contrast to WF, the EAF and NBF were not effective in increasing the first minimal clonic seizure (MCS) latency. Malondialdehyde (MDA) levels in both cortical and hippocampal tissues of PTZ group were significantly higher than those of control animals (p< 0.001). Pretreatment with WF, NBF, or EAF resulted in a significant reduction in the MDA levels of hippocampi (pConclusion: The present study showed that different fractions of C. sativum possess antioxidant activity in the brain and WF and EAF of this plant have anticonvulsant effects.
Journal title
Avicenna Journal of Phytomedicine AJP)
Serial Year
2016
Journal title
Avicenna Journal of Phytomedicine AJP)
Record number
2385346
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