Author/Authors :
Agha-Hosseini، Farzaneh نويسنده Department of Oral and Maxillofacial Medicine, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Oral Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran AND Department of Oral and Maxillofacial Medicine, The Academy of Medical Sciences, Tehran, Iran. Agha-Hosseini, Farzaneh , Mirzaii-Dizgah، Iraj نويسنده Department of Physiology, Aja University of Medical Sciences, Tehran, Iran Mirzaii-Dizgah, Iraj , Miri-Zarandi، NajmehSadaat نويسنده Department of Oral and Maxillofacial Medicine, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran Miri-Zarandi, NajmehSadaat
Abstract :
Unstimulated whole salivary p53 was evaluated in non-involved subjects, in patients suffering from oral lichen planus (OLP) and squamous cell carcinoma (SCC). A total of 34 patients with OLP, 24 patients suffering from oral SCC and 41 non-involved participants were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA. Data was analyzed by ANOVA followed by the Tukey post hoc test. Saliva p53 concentration in patients with SCC (5.36±1.08) was significantly higher than in healthy participants (0.41±0.04) and in patients suffering from OLP (0.94±0.31). This study could not confirm the precancerous nature of OLP based on the relatively low p53 expressions in comparison to SCC.
