One of the fundamental needs for the human is to have a workplace in which they can do their workappropriately. Worldwide energy crisis necessitated the construction of official buildings with smaller space and less air ventilation. This led to the reduction in air conditioning, accumulation of the contaminants in indoor, increased exposure, health threat concerning the staff in official environments. One of these problems is Sick Building Syndrome (SBS). The focus of this study was to observe the effect of SBS on the productivity of the staff. In addition, the work related effects of psychological and mental symptoms on the productivity were studied separately. This cross-sectional study was carried out on 105 staffs of an official building. In this study to observe the SBS a combination of questionnaires from the UK Health and Safety Organization and ESCO studies were used, and to survey the productivity, Hersey Blanchard model was utilized. To analyze the data Paired t-test, Tukey methods were used. This study shows that there is not a significant relation between the SBS and the productivity factor (P=0.061), not a significant relation between anxiety and distress (P=0.550) anger (P=0.287) forgetfulness (P=0.091) lack of sleep (P=0.323) and productivity. However the study shows a meaningful difference between irritability (P=0.034) distress (P=0.011) mental fatigue (P=0.029) and productivity. The mental SBS symptoms have impact on productivity. However more researches need to be done about the direct relation between SBS and the productivity level of staff.