Author/Authors :
Sanjari، Tahereh نويسنده Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran , , Hajjar، Toktam نويسنده Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran , , Momeni-Moghaddam، Madjid نويسنده Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran ,
Abstract :
Mesenchymal stem cells (MSCs) could differentiate into various types of tissues. These cells serve as a backup for
the regeneration and repair of tissues or cells after injury. A skin wound is defined as an injury to the skin that
needs to be restored. All types of cells in skin especially mesenchymal stem cells play important role in wound
healing process. In particular, paracrine signaling of MSC regulates the cellular responses at the wound site leading
to reduction of inflammation, stimulation of angiogenesis and induction of cell migration and proliferation. Because
of these abilities, MSCs are one of the most common stem cells for cell therapy in wound healing. This review
focuses on the role of MSCs on wound healing process. In addition, major phases of wound repair and challenges
of cell therapy are discussed
