Author/Authors :
Alipour، Fatemeh نويسنده M.Sc. student of Anatomy, Department of Anatomy, School of Medicine , , Oryan، Shahrbanoo نويسنده , , Sharifzadeh، Mohammad نويسنده , , Karimzadeh، Fariba نويسنده School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, Iran. Karimzadeh, Fariba , Kafami، Laya نويسنده Department of Pathobiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran , , Irannejad، Hamid نويسنده Department of Medicinal Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Mazandaran, Iran. Irannejad, Hamid , Amini، Mohsen نويسنده , , Hassanzadeh، Gholamreza نويسنده Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract :
Alzheimerʹs disease (AD) is the most prevalent neurodegenerative disorder. It is characterized by formation of amyloid plaques and neurofibrillary tangles in the brain, degeneration of the cholinergic neurons and neural cell death. This study was aimed to investigate the effect of a triazine derivative, C16H12Cl2N3S, on learning in an Alzheimerʹs rat model. Animals were divided into seven groups; each group contained seven animals.animals received no surgery and treatment; saline group: animals received normal saline after recovery; sham group: animals received 10% DMSO after recovery; STZ group (Alzheimerʹs model): animals received streptozotocin (STZ) in four and six days after recovery; T5, T10 and T15 groups: animals were treated with triazine derivative, C16H12Cl2N3S, at doses of 5, 10 and 15 µM, respectively. All drugs were injected intracerebroventricular. The spatial learning and histological assessment were performed in all groups. Animals in STZ group had more deficits in spatial learning than the control group in Morris water maze. C16H12Cl2N3S improved spatial learning significantly compared to STZ group. The CA1 pyramidal layer thicknesses in STZ group were reduced significantly compared to control group. C16H12Cl2N3S increased the CA1 pyramidal layer thickness in T15 group compared to STZ group. Current findings suggest C16H12Cl2N3S may have a protective effect on learning deficit and hippocampal structure in AD.
