Author/Authors :
Rastegar-Lari، Abdolaziz نويسنده Antimicrobial Resistant Research Center, Tehran University of Medical Sciences, Tehran, Iran Rastegar-Lari, Abdolaziz , Mohammadi-Barzelighi، Hajar نويسنده Antimicrobial Resistance Research Center, Tehran University of Medical Sciences, Tehran, IR Iran. Mohammadi-Barzelighi, Hajar , Arjomandzadegan، Mohammad نويسنده Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, IR Iran , , Nosrati، Rahim نويسنده Molecular Microbiology Research Center, Shahed University, Tehran, IR Iran , , Owlia، Parviz نويسنده ,
Abstract :
Background: Acinetobacter baumannii, is an important opportunistic pathogens responsible for nosocomial infections. The aim of this experiment was to determine prevalence of Class I Integron in A. baumannii strains isolated from burn patients in Mottahari Hospital and the drug susceptibility pattern. Methods: There were 69 Acinetobacter isolates, 68 (98.5%) were identified as A. baumannii. Antimicrobial susceptibility of these isolates were determined by a disk diffusion method. PCR assay for detection of blaOXA- 51 like gene (for identity confirmation) and intI was performed. Results: The most effective antibiotic for treating A. baumannii was colistin, followed by tetracyclin and tobramycin. The presence of Integron class I was detected in 14.49% of isolates. ESBL and carbapenemase production were observed in 10% and 24.6% of isolates, respectively. Conclusion: Due to the high resistance of strains lacking Integron I, the findings are although class I integrons are disseminated among clinical isolates of A. baumannii, at present research, they they do not play important role in dissemination of antibiotic resistance genes in Mottahari Hospital in Tehran, Iran
