Effect of Metformin on Diabetes Mellitus Prevention in Pregnant Women with Risk Factors
Niroomanesh، Shirin نويسنده Perinatalogy Devision, Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , , Dadashaliha، Masoumeh نويسنده Department of Gynecology and Obstetrics, Qazvin University of Medical Sciences, Qazvin, IR Iran , , Ahmadi، Farahnaz نويسنده , , Rahimi Sherbaf، Fatemeh نويسنده Department of Obstetrics and Gynecology, Mirza Koochackkhan Womens Hospital, Tehran University Rahimi Sherbaf, Fatemeh , Forghani، Forough نويسنده Zabol University of Medical Sciences, Zabol, Iran ,
Objective: This study evaluated the efficacy and safety of metformin on prevention of gestational diabetes mellitus in women with high risk of GDM.
Materials and methods: Total number of 189 pregnant women aged between 25 to 35, and 10 to 14 weeks pregnancy,admitted to Mirza Koochakkhan Hospital, Tehran in January 2008 - January 2009 entered to this randomized controlled clinical trial. The women had one of the three risk factors; history of GDM, family history of diabetes, or BMI ≥ 30 kg/m2, with normal results in the glucose challenge test (GCT) or the glucose tolerance test (GTT). Subjects were randomly split to two groups; 63 women (group A) who received metformin (500 mg, twice a day) and 126 women (group B) did not use metformin. Incidence of gestational diabetes was compared between two groups.
Results: The incidence of gestational diabetes was significantly different between two groups (%1.4 in group A, %15.4 in group B) (p<0.001). The study also showed that the insulin requirement was significantly different between two groups after developing GDM (group A %3.6, group B %9.5, p=0.001).
Conclusion: Using Metformin can effectively reduce the incidence of GDM in pregnant women at risk.