Author/Authors :
Ghasemi، Behzad نويسنده Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran. Ghasemi, Behzad , Beyzaei، Hamid نويسنده Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran. Beyzaei, Hamid , Hashemi، Sid-Hadi نويسنده Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran. Hashemi, Sid-Hadi , Majidiani، Hamidreza نويسنده 4Candidate of Veterinary Medicine, Faculty of Veterinary, Zabol University, Zabol, IR Iran Majidiani, Hamidreza
Abstract :
Introduction: Escherichia coli is one of the important pathogens in human with global
importance. Because of the necessity for identification and the use of novel antibacterial
compounds against E. coli, in this present study we focused on the antibacterial effects of
synthesized thiazole, imidazole and tetrahydropyridine derivatives on E. coli.
Methods: For evaluation of antibacterial effect, the disk diffusion method was applied to measure
the growth inhibition zone diameter and broth micro-dilution was performed to determine the
minimum inhibitory concentration (MIC).
Results: Assessing the antibacterial effect showed that only 6d derivative of thiazole had
inhibitory effect on E. coli and the other thiazole, imidazole and tetrahydropyridine derivatives
lacked any inhibitory result on this organism. The inhibitory effect of 6d derivative of thiazole
was MIC=125 and growth inhibition zone diameter of 16±0.1.
Discussion: The antibacterial effect of thiazole, imidazole and tetrahydropyridine derivatives
differs from each other and chemical linkages such as oxygen to thiazole ring in 6d derivative,
could have reinforced this effect. The next step is determination of the toxicity and therapeutic
effects in the laboratory animals
