Author/Authors :
Aghamohammadi، Asghar نويسنده , , Montazeri، Ali نويسنده PhD, Professor, Mental Health Research Group, Health Metrics Research Center, Iranian Institute for Health Sciences Re-search, Academic Center for Ed , , Abolhassani، Hassan نويسنده , , Saroukhani، Sepideh نويسنده Tehran Heart Center, Tehran University of Medical Sciences, Iran. , , Pourjabbar، Sarvenaz نويسنده Research Center for Immunodeficiency, Pediatrics Center of Excellence, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran Pourjabbar, Sarvenaz , Tavassoli، Mahmoud نويسنده Research Center for Immunodeficiency, Pediatrics Center of Excellence, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran Tavassoli, Mahmoud , Darabi، Behzad نويسنده Research Center for Immunodeficiency, Pediatrics Center of Excellence, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran Darabi, Behzad , Imanzadeh، Amir نويسنده Research Center for Immunodeficiency, Pediatrics Center of Excellence, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran Imanzadeh, Amir , Parvaneh، Nima نويسنده , , Rezaei، Nima نويسنده ,
Abstract :
Patients with primary antibody deficiencies (PAD) are susceptible to recurrent and chronic infections and a variety of complications. This study was performed to assess quality of life (QoL) of PAD patients who were under long term treatment and regular follow-up.Thirty six adults with proved diagnosis of PAD, who had received regular intravenous immunoglobulin replacement therapy, were enrolled in this study. The QoL of selected PAD patients was measured by Medical Outcomes Study 36-item Short-Form (SF-36) Health Survey questionnaire.
The patients with PAD showed significantly reduced scores in physical component in comparison with healthy age-sex matched control subjects (60.2±20.1 vs. 85.5±4.7, P<0.001). Mental component score was also significantly decreased in the patientʹs group (59.8±19.5 vs. 72.3±3.4, P=0.002). There was a reverse association between SF-36 scores and number of infections episodes (r=-0.73 P=0.003). The patients with long delay diagnosis showed significantly lower SF-36 scores (r=-0.62, P=0.003).
The patients with PAD who were diagnosed timely and managed appropriately seem to have lower complications and better QoL. However, the patients with severe phenotypes and long delay in diagnosis showed lower QoL, even in medical management.
