Author/Authors :
Khorsandi، Mohammad-Taghi نويسنده , , M. Amoli، Mahsa نويسنده Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran M. Amoli, Mahsa , Borghei، Hebatodin نويسنده Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran Borghei, Hebatodin , Emami، Hamed نويسنده Tehran university of medical sciences,Department of otorhinolaryngology , , Amiri، Parvin نويسنده Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , , Amirzargar، Ali نويسنده Immunogenetics Lab, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran Amirzargar, Ali , Yazdani، Nasrin نويسنده Tehran university of medical science, ,
Abstract :
Both genetic and environmental factors seem to play role in the etiology of Meniereʹs disease (MD). Several genes may be involved in susceptibility of MD including Human Leukocyte Antigens (HLA). The associations between MD and HLA alleles have been previously studied in other populations and certain HLA alleles were shown to be predisposing. The aim of this study was to determine the association between HLA-C allele frequencies and definite MD in patients who refer to Amir-Alam otolaryngology tertiary referral center in Tehran.
Patients with definite MD (N=22) enrolled according to the diagnostic criteria of American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS). Cases with all 3 symptoms of MD (Vertigo, Tinnitus and lower frequency of sensory-neural hearing loss) were included and those with suspected MD were excluded from study. HLA-Cw allele frequencies were determined in patients non-related healthy controls (N=91) using PCR -SSP.
We found that the frequency of HLACw*04 was significantly higher in patients compared to the controls [P = 0.0015, OR; 20, 95% CI (3.7-196.9)].
Our results revealed that HLA-C is a genetic predisposing factor in definite MD in patients who refer to Amir-Alam otolaryngology tertiary referral center.
