Author/Authors :
Abediankenari، Saeid نويسنده , , Yousefzadeh، Yousef نويسنده Department of Microbiology and Immunology , Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Yousefzadeh, Yousef , Majidi، Mohammad نويسنده Department of Medical Toxicology and Forensic Medicine, Urmia University of Medical Sciences, Urmia, Iran. , , Ghasemi، Maryam نويسنده Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran , , NASEHI، Mohammad Mahdi نويسنده Assistant Professor of Pediatrics, Department of Pediatrics, Sari, Iran , , GHAFFARI، JAVAD نويسنده , , Habibi Saravi، Reza نويسنده Department of Education and Research, Mazandaran Multiple Sclerosis Society, Sari, Iran Habibi Saravi, Reza , Abedini، Mahmoud نويسنده Assistant Professor, Department of Neurology, Mazandaran University of Medical science , , Elyasi، Mitra نويسنده Department of Microbiology and Immunology , Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Elyasi, Mitra
Abstract :
Multiple sclerosis (MS) is an autoimmune multifactorial degenerative disease with detrimental affliction on central nervous system. MHC class I chain- related geneA,B(MICA and MICB) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation.
The purpose of this study was to evaluate the MICA and MICB MRNA expression in multiple sclerosis patients. In this study, we evaluated MICA and MICB MRNA expression in the peripheral blood mononuclear cells by reverse transcryptase-polymerase chain reaction(RT-PCR) in MS patients and normal controls.
The results of this study showed that 32.6% of patients with progressive clinical outcome over expressed MICB genes in comparison with controls ( p=0.002).
It is concluded that the high expression of MICB gene in MS patients is an important criterion of MS disease that it may be due to the interaction between MICB and its receptor on CD8+T or NK cells.
