Title of article :
Analysis of IL-33 gene polymorphism (rs11792633 C/T) and risk of schizophrenia
Author/Authors :
-، - نويسنده University of sistan and Baluchestan Kordi-Tamandani, DorMohammad , -، - نويسنده university of Ferdowssi,Mashhad, Iran Bahrami, Ahmad Reza , -، - نويسنده university of Ferdowssi,Mashhad, Iran Sabbaghi-ghale-no, Raziye , -، - نويسنده University of sistan and Baluchestan Soleimani, Hanieh , -، - نويسنده University of sistan and Baluchestan Baranzehi, Tayebe
Issue Information :
فصلنامه با شماره پیاپی 0 سال 2016
Abstract :
Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (IL-33, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associated with the development of SCZ or not.DNA was isolated from the serum of 70 patients with SCZ and 70 healthy controls. The PCR based method was used for detection of the IL-33 polymorphism. The CT (OR=0.05, 95% CI: 0.003-0.057, P<0.001) andTT(OR=0.12, 95% CI: 0.028-0.46, P<0.001) genotypes significantly decreased the risk of SCZ. Our present findings indicate that the IL-33 polymorphism associated with the risk of SCZ.
Journal title :
Molecular Biology Research Communications
Journal title :
Molecular Biology Research Communications
