Author/Authors :
Rasoulinejad، Mehrnaz نويسنده , , Moradmand Badie، Sina نويسنده Department of Cardiology, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Moradmand Badie, Sina , Salehi، Mohammad Reza نويسنده Infectious Diseases Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran , , Seyed Alinaghi، Seyed Ahmad نويسنده Iranian Research Center for HIV/AIDS (IRCHA), Imam Khomeini Hospital , Tehran University of Medical Sciences, Tehran, Iran , , Dehghan Manshadi، Seyed Ali نويسنده Department of Infectious Diseases, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran Dehghan Manshadi, Seyed Ali , Zakerzadeh، Nahid نويسنده Iranian Research Center for HIV/AIDS (IRCHA), Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran. Zakerzadeh, Nahid , Foroughi، Maryam نويسنده Iranian Research Center for HIV/AIDS (IRCHA), Imam Khomeini Hospital , Tehran University of Medical Sciences, Tehran, Iran. , , Jahanjo Amin Abad، Fatemeh نويسنده Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Jahanjo Amin Abad, Fatemeh , Moradmand-Badie، Banafsheh نويسنده ,
Abstract :
Pulmonary hypertension is rare but is one of the complications that occur due to HIV infection. Symptoms of HIV-associated pulmonary arterial hypertension are often non-specific but the main symptom of the disease is dyspnea. In this cross-sectional study, we measured systolic pulmonary arterial pressure (SPAP) by echocardiographic methods among HIV-positive patients who received ART. This research is a descriptive, cross-sectional study of 170 HIV-positive patients that was conducted in Imam-Khomeini hospital, Tehran, Iran during 2011-2013. All patients regularly received antiretroviral therapy at least for recent 2 years. There were not any cardiopulmonary symptoms (cough, dyspnea, exertional fatigue and chest discomfort) in these patients. All participants underwent echocardiography to estimate SPAP. The participants comprised 108 males (63.5%) and 62 females (46.5%). The mean age of patients was 41 years old, and the mean duration of HIV infection was 5.5 years. The mean CD4 cell count was 401 cell/µl. The principal regimen of antiretroviral therapy included two nucleoside reverse transcriptase inhibitor (NRTI) and one non-nucleoside reverse transcriptase inhibitor (NNRTI) in the hospital. The mean of systolic pulmonary arterial pressure was 25 mmHg in the participants; 156 (93.4%) of them had SPAP ≤ 30 mmHg (normal), six (3.6%) had SPAP: 31-35 mmHg (borderline) and five (3%) had SPAP > 35 mmHg (pulmonary hypertension). Our results indicated a significant increase of pulmonary hypertension in asymptomatic HIV-positive patients that had no association with any other risk factor. Also, antiretroviral therapy was not a risk factor for pulmonary hypertension in this study.
