Author/Authors :
Sarraf، Payam نويسنده Iranian Center of Neurological Researches AND Department of Neurology, School of Medicine, Tehran University of Medical Sciences. Tehran, Iran Sarraf, Payam , Ghajarzadeh، Mahsa نويسنده Tehran University of Medical Sciences, Tehran, Iran , , Salarian، Babak نويسنده Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran. Salarian, Babak
Abstract :
Creutzfeldt-Jacob Disease is a prion disease which has a wide range of clinical presentations. Its diagnosis is not simple and clinical manifestation along with EEG, MR imaging findings and cerebrospinal fluid (CSF) analysis should be considered for a definite diagnosis. A-50-year-old woman referred with cognitive impairment, myoclonic jerks, mutism and difficulty in swallowing to our clinic. EEG (Electroencephalography) results showed bilaterally periodic sharp and slow-wave discharges. Protein 14-3-3 in CSF was detected. Magnetic resonance imaging (MRI) findings revealed hyperintensity of the caudate and putamen in diffusion-weighted imaging (DWI), T2 Weighted (T2W) sequences and Fluid-attenuated inversion-recovery (FLAIR) images. Patients who have progressive dementia should be evaluated by means of MR imaging and CSF analysis for CJD specific proteins should be considered.
