Antimicrobial Activity of Peganum harmala and Heracleum persicum Against Acinetobacter baumannii

The extracts of many plants have been used for their applications in the prevention of bacterial growth; however, these applications need more investigations. The major aim of the current study was to investigate the antimicrobial activity of an extract of the Peganum harmala flower and Heracleum persicum against Acinetobacter baumannii. The minimum inhibitory (MIC) concentrations Minimum Bactericidal Concentration of extract and essential oil were investigated by microdilution method and antibiotic resistance was evaluated using the disk diffusion test. In this study, the levels of MIC extract and essential oil of Peganum harmala were observed in ranges from 6.25 ppm to 12.5 ppm and 3.1 ppm to 25 ppm, respectively. The highest MIC value was observed as 12.5 ppm in A. baumannii. The levels of MIC extract and essential oil of Heracleum persicum were observed in ranges from 5 ppm to 20 ppm and 12.5 ppm to 10 ppm, respectively. The highest level of MIC extract and the highest essential oil value of Heracleum persicum were observed as 20 ppm and 10 ppm, respectively, in A. baumannii. Results of this study suggest that the extract alone of Peganum harmala and Heracleum persicum may be useful to treat bacterial infections