Author/Authors :
Mac Leod، Nicholas نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK , , Stobo، Jon نويسنده Cancer Research UK Clinical Trials Unit, University of
Glasgow, Glasgow, UK , , O’Rourke، Noelle نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK , , Hicks، Jonathan نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK , , Moore، Karen نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK , , Sankaralingam، Marimuthu نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK , , Oommen، Kurian نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK , , Kelly، Caroline نويسنده Cancer Research UK Clinical Trials Unit, University of
Glasgow, Glasgow, UK , , McMahon، Lynn نويسنده Cancer Research UK Clinical Trials Unit, University of
Glasgow, Glasgow, UK , , Poon، Fat Wi نويسنده West of Scotland PET-CT Centre, Gartnavel General
Hospital, Glasgow, UK , , Han، Sai نويسنده West of Scotland PET-CT Centre, Gartnavel General
Hospital, Glasgow, UK , , Findlay، Caroline نويسنده West of Scotland PET-CT Centre, Gartnavel General
Hospital, Glasgow, UK , , Chalmers، Anthony نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK , , Fallon، Marie نويسنده Edinburgh Cancer Research Centre, University of Edinburgh,
Edinburghs, UK , , Laird، Barry J. نويسنده Beatson West of Scotland Cancer Centre, Glasgow,
UK ,
Abstract :
Background: Positron emission tomography computerized tomography (PET-CT) is useful in radiotherapy planning for lung cancer. However, its role in malignant pleural mesothelioma (MPM) is unknown.
Objectives: This exploratory study investigated the possible role for PET-CT in radiotherapy planning for MPM.
Patients and Methods: Patients receiving radiotherapy for the treatment of pain in MPM, had fluorodeoxyglucose (FDG) PET-CT scanning in addition to their standard CT scan. PET-CT images were then fused with CT planning images, termed Planning-PET-CT. Target volume delineation was undertaken first using CT and subsequently incorporated Planning-PET-CT. Planning treatment volume (PTV), conformity index (CI), mean distance to conformity (MDC), center of gravity distance (CGD) and standard uptake values (SUV) were examined.
Results: Sixteen patients were recruited into the study. PET-CT upstaged nine patients. No association between SUV max and either survival or pain response was seen. Volumes contoured using Planning-PET-CT differed markedly from those outlined using CT alone as shown by the following parameters: CI = 0.3 (0.24 - 0.38). MDC = 21.47 (16.73 - 33.70) and CGD = 16.40 (11.80 - 33.87). The median percentage of over contouring was 44.00% (34.33 - 72.50) with 46.67% under contoured (34.00 - 55.00).
Conclusions: PET-CT alters the position of the PTV in MPM and upstaged a proportion of patients. Further work to elucidate the role of Planning-PET-CT in target volume definition is justified.
