Author/Authors :
Bahtouee، Mehrzad نويسنده Department of Internal Medicine (Division of Pulmonary),
Bushehr Medical Center Hospital, Bushehr University of Medical
Sciences, Bushehr, Iran , , Saberifard، Jamshid نويسنده Department of Radiology, Bushehr Medical Center Hospital,
Bushehr University of Medical Sciences, Bushehr, Iran , , Seyed Javadi، Hamid نويسنده , , Nabipour، Iraj نويسنده , , Malakizadeh، Hasan نويسنده Department of Internal Medicine (Division of Pulmonary),
Bushehr Medical Center Hospital, Bushehr University of Medical
Sciences, Bushehr, Iran , , Monavvarsadegh، Gholamhossein نويسنده Department of Internal Medicine (Division of Pulmonary),
Bushehr Medical Center Hospital, Bushehr University of Medical
Sciences, Bushehr, Iran , , Ilkhani Pak، Hoda نويسنده The Persian Gulf Nuclear Medicine Research Center, Bushehr
University of Medical Sciences, Bushehr, Iran , , Sadeghi، Azadeh نويسنده The Persian Gulf Nuclear Medicine Research Center, Bushehr
University of Medical Sciences, Bushehr, Iran , , Assadi، Majid نويسنده 1The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran ,
Abstract :
The discrimination of inactive inflammatory processes from the active form of the disease is of great importance in the management of interstitial lung disease (ILD). The aim of this study was to determine the efficacy of 99mTc-IgG scan for the detection of severity of disease compared to high-resolution computed tomography (HRCT) and pulmonary function test (PFT). Eight known cases of ILD including four cases of Mustard gas (MG) intoxication and four patients with ILD of unknown cause were included in this study. A population of six patients without lung disease was considered as the control group. The patients underwent PFT and high-resolution computed tomography scan, followed by 99mTc-IgG scan. They were followed up for one year. 99mTc-IgG scan assessment of IgG uptake was accomplished both qualitatively (subjectively) and semiquantitatively. All eight ILD patients demonstrated a strong increase in 99mTc-IgG uptake in the lungs, compared to the control patients. The 99mTc-IgG scan scores were higher in the patient group (0.64[95% confidence interval(CI)=0.61-0.69])) than the control group (0.35(0.35[95% CI=0.28-0.40]), (P<0.05)). In patients, a statistically significant positive correlation was detected between 99mTc-IgG scan and HRCT scores (Spearman’s correlation coefficient = 0.92, P < 0.008). The 99mTc-Human Immunoglobulin (HIG) scores were not significantly correlated with PFT findings (including FVC, FEV1, FEV1/FVC), O2 saturation and age ( P values > 0.05). There were no significant correlations between 99mTc-IgG score and HRCT patterns including ground glass opacity, reticular fibrosis and honeycombing (P value > 0.05). The present results confirmed that 99mTc-IgG scan could be applied to detect the severity of pulmonary involvement, which was well correlated with HRCT findings. This data also showed that the 99mTc-IgG scan might be used as a complement to HRCT in the functional evaluation of the clinical status in ILD; however, further studies are recommended
