Title of article :
Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced
Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized,
Placebo-Controlled Trial
Author/Authors :
Javadzadeh Bolouri، Abbas نويسنده Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran , , Pakfetrat، Atessa نويسنده Department of Oral Medicine, Faculty of Dentistry, Mashhad University of Medical Science, Mashhad, Iran Pakfetrat, Atessa , Tonkaboni، Arghavan نويسنده Department of Oral Medicine, School of Dentistry, Tehran
University of Medical Sciences, Tehran, IR Iran , , Aledavood، seyed AMIR نويسنده Cancer Research Center , Mashhad University of Medical Sciences, Mashhad, Iran , , Fathi Najafi، Mohsen نويسنده Department of Veterinary Research and Biotechnology, Razi
Vaccine and Serum Research Institute, Mashhad, IR
Iran , , Delavarian، Zahra نويسنده Mashhad university of medical science,Department of oral medicine , , Shakeri، Mohammad Taghi نويسنده , , Mohtashami، Azade نويسنده Cancer Research Center, Mashhad University of Medical
Sciences, Mashhad, IR Iran ,
Abstract :
Background: Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients.
Objectives: Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer.
Patients and Methods: In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading.
Results: We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05).
Conclusions: This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis.
