Author/Authors :
Shams Alizadeh، Narges نويسنده Kurdistan Research Center for Social Determinants of Health, Department of Psychiatry, Qods Hospital, Kurdistan University of Medical Sciences, Sanandaj, IR Iran , , Maroufi، Azad نويسنده Kurdistan University of Medical Sciences, Sanandaj, Iran. , , Nasseri، Karim نويسنده Dept. of Anesthesiology, Kurdistan Research Center for Social Determinants of Health, School of Medicine, Kurdistan University of Medical Sciences, Sa Nasseri, Karim , Sadeghi Najafabadi، Seyed Hosein نويسنده Department of Psychiatry, Qods Hospital, Kurdistan University of Medical Sciences, Sanandaj, IR Iran , , Mousavi Taghiabad، Ali نويسنده Department of Psychiatry, Qods Hospital, Kurdistan University of Medical Sciences, Sanandaj, IR Iran , , Gharibi، Fardin نويسنده Vice Chancellor of Research, Kurdistan University of Medical Sciences, Sanandaj, Iran , , Esfandiari، Gholam Reza نويسنده Department of Psychiatry, Qods Hospital, Kurdistan University of Medical Sciences, Sanandaj, IR Iran ,
Abstract :
Background: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response.
Objectives: We aimed to determine the effect of Ketamine as a synergistic antidepressant and anesthetic agent on MDD in electroconvulsive therapy (ECT).
Patients and Methods: Twenty-two patients with MDD received Ketamine and Propofol as anesthetic agents compared with 20 patients as the control group who received Propofol in a double-blind randomized clinical trial. The Hamilton rating scale for depression was used to determine the changes in symptoms severity during ECT and a 2-week follow-up.
Results: Both groups showed a reduction in depression severity, but there was no significant difference between the groups in the recovery process (P = 0.92). However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042).
Conclusions: This study could not show the effect of Ketamine on depression recovery in a 2-week follow-up period. Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT.
