Title of article :
Effect of Vitamin A Supplementation on fatigue and depression in Multiple Sclerosis patients: A Double-Blind Placebo-Controlled Clinical Trial
Author/Authors :
Bitarafan، Sama نويسنده Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Bitarafan, Sama , Saboor-Yaraghi، Aliakbar نويسنده Department of Molecular and Cellular Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Saboor-Yaraghi, Aliakbar , Sahraian، Mohammad Ali نويسنده , , Soltani، Danesh نويسنده Department of Neurology, Iranian Center of Neurological Research, Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Soltani, Danesh , NAFISSI، Shahriar نويسنده MD, Associate Professor of Neurology, Neurology Department, Tehran University of Medical Sciences, Tehran,Iran , , TOGHA، Mansoureh نويسنده Neurology Department, Sina Hospital, Tehran University of Medical Science, Tehran, Iran , , Beladi Moghadam، Nahid نويسنده Assistant Professor, Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Beladi Moghadam, Nahid , Roostaei، Tina نويسنده Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran AND Interdisciplinary Neuroscience Research Program, Tehran University of Medical Sciences, Tehran, Iran AND Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada Roostaei, Tina , Mohammadzadeh Honarvar، Niyaz نويسنده Department of Cellular and Molecular Nutrition, Faculty of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Mohammadzadeh Honarvar, Niyaz , Harirchian، Mohammad Hossein نويسنده Department of Neurogenetics, Iranian Centre of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran ,
Issue Information :
دوماهنامه با شماره پیاپی 0 سال 2016
Pages :
7
From page :
13
To page :
19
Abstract :
Decreasing the population and activation of inflammatory T helper cells in multiple sclerosis (MS) patients using vitamin A derivatives (retinoic acids) has been well documented. The present study determined the effect of vitamin A supplementation on psychiatric signs in MS patients. The subjects were 101 relapsing-remitting MS patients enrolled in a placebo-controlled randomized clinical trial. The treatment group was administered 25000 IU/d retinyl palmitate (RP) for 6 months followed by 10000 IU/d RP for another 6 months. The results for baseline characteristics, modified fatigue impact scale and Beck Depression Inventory-II were recorded at the beginning and end of the one-year study. The non-normal distribution data was compared between groups using a nonparametric test and normal distribution data was analyzed using a parametric test. (ClinicalTrials.gov Identifiers: NCT01417273). The results showed significant improvement in the treatment group for fatigue (p=0.004) and depression (p=0.01). Vitamin A supplementation helped during interferon therapy in the treatment process and improved psychiatric outcomes for anti-inflammatory mechanisms.
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Serial Year :
2016
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Record number :
2387926
Link To Document :
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