Author/Authors :
Sarrami-Foroushani، Ali نويسنده Department of Chemical Engineering, Isfahan University of
Technology, Isfahan, Iran , , Nasr Esfahany، Mohsen نويسنده Faculty of Chemical Engineering, Isfahan University of Technology, Isfahan, I.R. IRAN , , Saligheh Rad، Hamidreza نويسنده Medical Physics and Biomedical Engineering Department,
Tehran University of Medical Sciences, Tehran, Iran , , Firouznia، Kavous نويسنده , , Shakiba، Madjid نويسنده , , Ghanaati، Hossein نويسنده ,
Abstract :
Hemodynamics is thought to play an important role in the mechanisms
responsible for initiation, growth, and rupture of intracranial
aneurysms. Computational fluid dynamic (CFD) analysis is used to assess
intra-aneurysmal hemodynamics. This study aimed to investigate the
effects of variations in heart rate and internal carotid artery (ICA)
flow rate on intra-aneurysmal hemodynamics, in an ICA aneurysm, by using
computational fluid dynamics. Computed tomography angiography (CTA) was
performed in a 55 years old female case, with a saccular ICA aneurysm,
to create a patient-specific geometrical anatomic model of the aneurysm.
The intra-aneurysmal hemodynamic environments for three states with
different flow and heart rates were analyzed using patient-specific
image-based CFD modeling. Results showed significant changes for the
three simulated states. For a proportion of the states examined, results
were counterintuitive. Systolic and time-averaged wall shear stress and
pressure on the aneurysm wall showed a proportional evolution with the
mainstream flow rate. Results reinforced the pivotal role of vascular
geometry, with respect to hemodynamics, together with the importance of
performing patient-specific CFD analyses, through which the effect of
different blood flow conditions on the aneurysm hemodynamics could be
evaluated.
