Title of article
Design, synthesis and biological evaluation of 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaffold as antimicrobial and antioxidant candidates
Author/Authors
Gurunanjappa ، Pavithra نويسنده Post Graduate Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysuru 570005, India , , Kariyappa، Ajay Kumar نويسنده Post Graduate Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysuru 570005, India ,
Issue Information
فصلنامه با شماره پیاپی 19 سال 2016
Pages
14
From page
109
To page
122
Abstract
A series of semicarbazones, thiosemicarbazones, 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaffold were designed and synthesized. All the synthesized new compounds were characterized by 1H NMR, 13C NMR, MS and elemental analysis. The synthesized compounds were screened to probe their in vitro antimicrobial activity against bacteria and fungi species. The structure-activity relationship of the synthesized compounds was studied. The compounds displayed good to excellent potency against tested microorganisms. The in vitro antioxidant activities of the 1,3,4-oxadiazoles/thiadiazoles were evaluated by DPPH, hydroxyl and nitric oxide radical scavenging assay. Among the tested compounds, compound with chloro substitution showed good antioxidant potential.
Journal title
Current Chemistry Letters
Serial Year
2016
Journal title
Current Chemistry Letters
Record number
2388370
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