Title of article :
[3+2] Cycloadditions of 1-halo-1-nitroethenes with (Z)-C-(3,4,5-trimethoxyphenyl)-N-methyl-nitrone as regio- and stereocontrolled source of novel bioactive compounds: preliminary studies
Author/Authors :
Jasi?ski، Radomir نويسنده , , Dresler، Ewa نويسنده Institute of Heavy Organic Synthesis „Blachownia", Energetyk?w Str. 9, 47-225 K?dzierzyn-Ko?le, Poland , , Mikulska، Maria نويسنده Institute of Organic Chemistry and Technology, Cracow University of Technology, Warszawska Str. 24, 31155 Cracow, Poland , , Polewski، Daniel نويسنده Institute of Organic Chemistry and Technology, Cracow University of Technology, Warszawska Str. 24, 31155 Cracow, Poland ,
Abstract :
Preliminary experiments shows, that [3+2] cycloadditions reactions proceeds with full regioselectivity and high stereoselectivity. In consequence, 3,4-trans-2-methyl-3-(3,4,5-trimethoxyphenyl)-4-halo-4-nitroisoxazolidines are forming as predominantly (or sole) products. Additionally, prognosis for the synthesized compounds to be potential ingredients of drugs is good.
