Author/Authors :
Ramezanali، Fariba نويسنده Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Khalili، Gholamreza نويسنده Epidemiology and Reproductive Health Department, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Arabipoor، Arezoo نويسنده Endocrinology and Female Infertility Department, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Bagheri Lankarani، Narges نويسنده Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Moini، Ashraf نويسنده ,
Abstract :
Background: The endometrial hyperplasia measured by ultrasound in polycystic ovary
syndrome (PCOS) women is strongly related to pathologic endometrial thickness, but
there is no consensus on the relation between serum luteinizing hormone (LH) and either
of these factors: pathologic endometrial hyperplasia and body mass index (BMI).
Materials and Methods: In this observational cross-sectional study, three hundred fifty
infertile PCOS women were involved in this research. An endometrial biopsy was taken
by using a pipelle instrument, regardless of menstrual cycle’s day and all samples were
reported by the same pathologist. Basal serum LH level was compared between two
subgroups (hyperplasia and non-hyperplasia). The intended population was divided into
three groups according to BMI and basal serum LH, later on the comparison was made in
three groups. Chi-square test was applied to compare nominal variables between groups.
Mann-Whitney U, and one way ANOVA tests were used to compare means on the basis
of the result of normality test.
Results: The frequency of endometrial hyperplasia was 2.6%. Endometrial thickness
in the patients with endometrial hyperplasia was significantly higher than that of a
normal endometrium (10.78 ± 3.70 vs. 7.90 ± 2.86 respectively, P=0.020). There was
no relation between endometrial hyperplasia and serum LH (P=0.600). The ANOVA
test showed serum LH levels were not the same among three BMI groups (P=0.007).
Post hoc test was also performed. It showed that the LH level in normal BMI group
was significantly higher than those of other groups (P=0.005 and P=0.004), but there
was no statistical difference between overweight and obese groups (P=0.8). We found
no relationship between BMI and endometrial thickness in PCOS patients (P=0.6).
Conclusion: Sonographic endometrial stripe thickness is predictive for endometrial hyperplasia
in PCOS women. We could not find out any relationship between serum LH level
and BMI with endometrial thickness in PCOS patients. However, our study confirmed a
diverse relationship between serum LH level and BMI in PCOS patients.
