Author/Authors :
Ataie ، Amin Amin نويسنده Cellular and Molecular Biology Research Center, Babol University of Medical Science, Babol, Iran. Ataie , Amin Amin , Ataee، Ramin Ramin نويسنده Pharmaceutical Sciences Research Center, Department of Pharmacology and Toxicology Mazandaran University of Medical Sciences, Sari, Iran. Ataee, Ramin Ramin , Shadifar، Mohammad Mohammad نويسنده Pastor Institute of Iran, Tehran, Iran Shadifar, Mohammad Mohammad
Abstract :
Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from international medical journals and academic informationsʹ sites. According to many studies, antioxidants could reduce toxic neuronal damages and many studies confirmed the efficacy of polyphenol antioxidants in fruits and vegetables to reduce neuronal death and to diminish oxidative stress. This systematic review showed the antioxidant activities of phytochemicals which play as natural neuroprotectives with low adverse effects against some neurodegenerative diseases as Parkinson or Alzheimer diseases.
