Author/Authors :
Eftekhari، Sanaz نويسنده Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Eftekhari, Sanaz , Mehrabi، Soraya نويسنده Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, IR Iran , , Karimzadeh، Fariba نويسنده School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, Iran. Karimzadeh, Fariba , Joghataei، Mohammad Taghi نويسنده Department of Anatomy, Cellular and Molecular Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran , , Khaksarian، Mojtaba نويسنده Department of Physiology, Lorestan University of Medical Sciences Khaksarian, Mojtaba , Hadjighassem، Mahmoud Reza نويسنده Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences Hadjighassem, Mahmoud Reza , Katebi، Majid نويسنده , , Soleimani، Mansooreh نويسنده Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract :
Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide a relatively comprehensive account of the relation between -509C/T gene polymorphisms of TGF-β1 and susceptibility to IS.
Methods: Male Wistar rats were divided into sham (receiving phosphate buffered saline within dorsal hippocampus), pilocarpine (epileptic model of TLE), single injection BDNF (epileptic rats which received single high dose of BDBF within dorsal hippocampus), and multiple injections BDNF (epileptic rats which received BDNF in days 10, 11, 12, and 13 after induction of TLE) groups. Their electrocorticogram was recorded and amplitude, frequency, and duration of spikes were evaluated.
Results: Amplitude and frequency of epileptiform burst discharges were significantly decreased in animals treated with BDNF compared to pilocarpine group.
Conclusion: Our findings suggested that BDNF may modulate the epileptic activity in the animal model of TLE. In addition, it may have therapeutic effect for epilepsy. More studies are
necessary to clarify the exact mechanisms of BDNF effects.
