Author/Authors :
Izadi، A نويسنده Department of Medical Mycology and Parasitology,School of Medicine,Kerman University of Medi cal Sciences,Kerman,Iran , , Asadikaram ، G نويسنده Physiology Research Center,Institute of Neuropharmacology and Department of Biochemistry,School of Medicine,Kerman University of Medical Sciences,Kerman,Iran , , Nakhaee ، N نويسنده Neuroscience Research Center,Kerman University of Medical Sciences,Kerm an,Iran , , Hadizadeh ، S نويسنده Department of Medical Mycology and Parasitology,School of Medicine,Kerman University of Medi cal Sciences,Kerman,Iran , , Ayatollahi Mousavi ، A نويسنده Department of Medical Mycology and Parasitology,School of Medicine,Kerman University of Medi cal Sciences,Kerman,Iran ,
Abstract :
Background and Purpose:
TGF
-
B is a potent regulator and suppressor of the immune system and overproduction of this
cytokine may contribute to immunosuppression in HIV
-
infected patients. Increasing population of immunosuppressed patients
has resulted in increasingly frequent of fu
ngal infections, including oral candidiasis. The aim of this study was to evaluate the
plasma levels of TGF
-
B under
in vivo
conditions
.
Materials and Methods:
Seventy
-
two samples were obtained from the oral cavities of HIV
-
positive Iranian patients and
cu
ltured on Sabouraud’s dextrose agar and CHROMagar. Also blood samples were obtained to assess TGF
-
B levels using
ELISA technique.
.
Results:
Thirty
-
three out of 72 oral samples yielded
candida
isolates,
Candida albicans
in 14 and non
-
albicans
candida
in
19
.Fungal infection decreased significantly more TGF
-
B level than non
-
fungal infection also HIV negative were
significantly more TGF
-
B than HIV
positive
.
Conclusion:
Our findings suggest a significant interaction between fungal infection and HIV on expressio
n of
Transforming Growth Factor Beta
