Author/Authors :
Abastabar، m نويسنده Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran Univer sity of Medical Sciences, Sari, Iran , , Shokohi ، t نويسنده Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran Univer sity of Medical Sciences, Sari, Iran , , Rouhi Kord ، r نويسنده Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran , , Badali ، H نويسنده Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran Univer sity of Medical Sciences, Sari, Iran , , HASHEMI، S.J. نويسنده , , Ghasemi ، z نويسنده Department of Medical Parasitology and Mycology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , , Ghojoghi ، A نويسنده Toxoplasmosis Research Center, Mazandaran Un iversity of Medical Sciences, Sari, Iran , , Baghi ، N نويسنده Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran , , Abdo llahi ، M نويسنده Department of Microbiology and Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , , Hosseinpoor، S نويسنده Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran , , Rahimi ، N نويسنده Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran , , Seifi ، Z نويسنده Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran , , Gholami، S نويسنده Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran Univer sity of Medical Sciences, Sari, Iran , , Haghani ، I نويسنده Invasive Fungi Research Center (IFRC), Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran Univer sity of Medical Sciences, Sari, Iran , , Jabari، MR نويسنده Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran , , Pagheh ، A نويسنده Toxoplasmosis Research Center, Mazandaran Un iversity of Medical Sciences, Sari, Iran ,
Abstract :
Background and Purpose:
Candida
species
are the most common organisms involved in superficial fungal infections,
worldwide. Although econazole
is among the most frequently used topical formulations for the treatment of candidiasis,
no information is available regarding the susceptibility profiles of
Candida
species in Iran
.
Materials and Methods:
In vitro
susceptibility of 100 clinical
Candida
isolates belonging to 6 species from superficial
candidiasis of Iran towards
to econazole was compared with three other common antifungal agents including
itraconazole, fluconazole, and miconazole. Minimum inhibitory concentrations (MICs) values were analyzed according
to the Clinical and Laboratory Standards Institute (CLSI) M38
-A3 document. All isolates were previously identified to
the species level, using polymerase chain reaction
-restriction fragment length polymorphism (PCR
-RFLP) on ITS
region.
Results:
The MIC of econazole, itraconazole, miconazole, and fluconazole were wit
hin the range of 0.016-
16, 0.032-
16, 0.016-
16, and 0.25-
64 ?g/ml, respectively. In general, econazole and miconazole were more active against
Candida
isolates, compared to the other two agents
.
Conclusion:
The present study demonstrated that for
Candida albicans
isolates, miconazole and econazole had the best
effect, but in non-
albicans Candida species, itraconazole and miconazole displayed more activity than other antifungal
agents
.
