Author/Authors :
Behmanesh، Fatemeh نويسنده 1Department of Pediatric Allergy-immunology, Mashhad University of Medical Science, Mashhad, Iran Behmanesh, Fatemeh , Ashrafzadeh، Farah نويسنده , , Varasteh، Abdoreza نويسنده Department of Immunology and Allergy, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran Varasteh, Abdoreza , Shakeri، Abdoreza نويسنده Department of Pediatrics, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran Shakeri, Abdoreza , Shahsavand، Shabnam نويسنده Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran Shahsavand, Shabnam
Abstract :
Febrile collected from members of both groups and serum samples were prepared. Interleukin 1β concentrations were measured using a commercial Enzyme-linked immunosorbent assay (ELISA) kit.
We found that there was a difference in serum levels of Interleukin 1β between FC and control group but it was not significant. This result may be due to the low number of samples or the result of Interleukin 1β binding to some large proteins such as α2- macroglobolin, complement and soluble type 2 Interleukin 1 receptor, that affected the free Interleukin 1β concentration.
We could not find a significant relationship between serum Interleukin 1β concentration and FC.convulsion (FC) is the most common type of seizure in childhood that occurs in 2-5 % of the children younger than 6 years. Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. Thus we measured IL-1ß in febrile children with or without seizure.
60 febrile children (6 months to 5 years old) were divided in two groups, one group consisted of 30 children with FC, the other group consisting of 30 children without seizure which served as control. Blood samples were
