Evaluation of interleukin 1β in febrile convulsion.

Febrile collected from members of both groups and serum samples were prepared. Interleukin 1β concentrations were measured using a commercial Enzyme-linked immunosorbent assay (ELISA) kit. We found that there was a difference in serum levels of Interleukin 1β between FC and control  group but  it was not  significant. This result may be due to  the low number  of samples  or  the  result  of  Interleukin  1β  binding  to  some  large proteins  such  as  α2- macroglobolin, complement and soluble type 2 Interleukin 1 receptor, that affected the free Interleukin 1β concentration. We could not find a significant relationship between serum Interleukin 1β concentration and FC.convulsion (FC) is the most common type of seizure in childhood that occurs in 2-5 %  of  the  children younger than  6  years. Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. Thus we measured IL-1ß in febrile children with or without seizure. 60 febrile children (6 months  to 5 years old) were divided in two groups, one group consisted of 30 children with FC, the other group consisting of 30 children without seizure which served as control. Blood samples were