Author/Authors :
Aghili، Hosseinagha نويسنده Department of Orthodontics , , Fatahi Meybodi، Seyed Amir Reza نويسنده Department of Orthodontics , , Danesh Ardekani، Mohammed نويسنده Department ofDepartment of Oral Pathology , , Bemanianashkezari، Mohammad Hassan نويسنده Department of Pediatric Dentistry , , Modaresi، Jalil نويسنده Department of Endodontics , , Masomi، Yousef نويسنده Departments of Oral and Maxillofacial Radiologist , , Goldani Moghadam، Mahdjoube نويسنده Postgraduate Student, Dental Research Center, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran. Goldani Moghadam, Mahdjoube
Abstract :
Background: The aim of this study was to evaluate the hypothesis that budesonide increases the
susceptibility of teeth to root resorption during the course of orthodontic treatment.
Materials and Methods: A randomized controlled trial design (animal study) was employed.
Budesonide was administered in test group for 14 days during which orthodontic force was applied
to upper right molar. Afterwards, root resorption was measured on mesio-cervical and disto-apical
parts of the mesial root on transverse histological sections. ANOVA and Bonfferoni tests were
used. Statistical signifi cance was considered to be P ? 0.05.
Results: In general, the subgroups in which the force was applied showed signifi cantly greater root
resorption. Where force was applied there was no signifi cant difference, whether budesonide was
administered or not. While where there was no force, a group who received budesonide showed
signifi cantly greater root resorption than the other, unless at the coronal level where the difference
was not signifi cant.
Conclusion: Within the limitations of this study, it seems budesonide could increase root resorption,
but in the presence of orthodontic force this effect is negligible.
