Author/Authors :
Hosseinzadeh، Leila نويسنده , , Aliabadi، Alireza نويسنده , , Kalantari، Masoud نويسنده , , Mostafavi، Abolfazl نويسنده 4Department of Pharmaceutics and Isfahan Pharmaceutical Sciences Research Center, School of pharmacy and pharmaceutical science, Isfahan University of Medical Sciences, I.R. Iran. , , Rahmani Khajouei، Marzieh نويسنده 2Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. ,
Abstract :
Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole groups and quinazoline derivatives, in this study a series of quinazolinone-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (quinazolinones and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line. K6 and C were most active compounds against MCF7 and K6 showed best cytotoxicity on HT-29 cell line.
