Author/Authors :
Hassanzadeh Delui، Mahdy نويسنده Department of Cardiology, Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , , Fatehi، Hedayatollah نويسنده , , Manavifar، Morteza نويسنده Department of Cardiology, Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , , Amini، Maral نويسنده Department of Nutrition, School of Medicine, Cardiovascular Research Center, Mashhad University of Medical Sciences, University Paradise, Azadi Square , , Ghayour-Mobarhan، Majid نويسنده MD, PhD, Cardiovascular Research Center, Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Science, Mashhad , , Zahedi، Mahdi نويسنده Department of Cardiology, Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , , Ferns، Gordon نويسنده Brighton and Sussex Medical School, Division of Medical Education, Mayfield House, Falmer, Brighton, BN1 9PH ,
Abstract :
Background: Because of the conflicting results from previous
studies regarding the efficacy of ginseng on lipid profile and
anti?inflammatory and anti?proliferative activities of its
components, we aimed to evaluate the effects of Panax ginseng on
lipid profile, pro?oxidant – anti?oxidant status and high?sensitivity
C reactive protein (hs?CRP) levels.
Methods: Forty Iranian hyperlipidemic patients were randomly
assigned to placebo (n = 20) or control (n = 20) groups in this
double?blind randomized controlled trial. The ginseng or placebo was
taken two capsules twice a day for 8 weeks. Total cholesterol (TC),
triglyceride (TG), low density lipoprotein cholesterol (LDL?C), high
density lipoprotein cholesterol (HDL?C), fasting blood glucose,
serum creatinine and hs?CRP levels and pro?oxidant – anti?oxidant
balance (PAB) were estimated before and after intervention.
Results: There were no significant differences between the two
groups with respect to changes in serum TG, LDL?C, HDL?C, and
TC/HDL?C levels. Nor were there significant differences between
the two groups with respect to changes in hs?CRP level and PAB
from baseline to week 8.
Conclusions: Our study demonstrates that ginseng does not have
significant effects on lipid profile, Hs?CRP level and PAB. Further
clinical studies, with a larger sample size, more prolonged period of
therapy are needed to investigate the therapeutic effects of ginseng.
