The Effects of Aerobic Exercise on NF-?B and TNF-? in Lung Tissue of Male Rat

Background: Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the lung response have not been investigated. The present study evaluated the effect of aerobic exercise on the lung inflammatory. Materials and Methods: 12 adult male Wistar rats were divided to 2 groups: A: control (n=6), B: aerobic exercise (five times per week for 4 week; n=6). The gene expression of NF-?B and TNF-? were analyzed in lung tissue by Real time–PCR. In order to determine the significant differences between groups independent ttest were used. Results: Aerobic exercise inhibited the gene expression of NF-?B and TNF-?. But there was no significant difference between A and B groups for TNF-? and NF-?B. Conclusion: We conclude that four week aerobic exercise decrease inflammatory status in lung tissue. Our results indicate a need for human studies that evaluate the lung responses to aerobic exercise