There are many published articles which cover current and future challenges of epidemiology. However, up until now, most of them are written by developed world epidemiologists. Therefore, despite a common use of assumptions, they did not have the opportunity to discuss the different range of practical tasks and priorities away from developed countries. The topics covered are; facing poverty, non-democratic government that has links to developed countries, man-made and natural disasters, handling low-quality data and accessing it, and finally improving contribution to the world epidemiological knowledge for the 21st century.